[ harmful effect of quinolone [pefloxacine] on immature cartilage in juvenile rat]

ABSTRACT

The aim of our study was definition of the exact mechanism by which quinolone harm the immature cartilage causing arthropathy, and upon these results we can determine the suitable treatment for this damage. This effect was studied in four groups of juvenile wistar rats as following1- normal group.2- the group of pefloxacine with a dose 15 mg/kg per day for one month. 3- the group of pefloxacine 15mg/kg per day for one month with addition of the magnesium ions with compensate amount 84mg/kg per art. 4- the group of pefloxacine 15mg/kg per day for one month with addition of vitamin E with compensate amount75mg/kg per rat. The drugs were administered by incubation tube for one months, and at the end of the experiment blood samples were took from animals hearts preparing for measuring malondialdehide, then animals were scarified and the maximum extension angle of the knee joints was measured, then we put the joints in the formol for the histological study. Pefloxacine increased the values of maximum extension angle significantly in compare to the normal group and the control group, with significant improvement in the group of magnesium ions and the group of vitamin E but non of each group could return the cartilage to the normal condition. The results of malondiadehyde assay inssure the effect of free radicals in this arthropathy. Histological study pefloxacine damage significantly the cartilage and the damage was decreased in the addition of magnesium or vitamin E. There is a lot of factors participate in causing the arthropathy which induced by taking quinolone and this pathology don't confine on the participate of magnesium ions or oxidative stress.