[Correlation between parathormone and coronary artery calcium scoring and coronary artery disease]

ABSTRACT

It has been shown that coronary artery calcium scoring [CACS] can be used as a diagnostic method in coronary artery disease [CAD]. The relationship between CACS and calcium metabolism in the body has been shown. The arterial calcification is an organized process similar to bone formation which is controled by parathormone [PTH]. The relationship between PTH as an osteoregulatory factor and CACS has been also indicated. In this study, we tried to assess the value of serum PTH and CACS in patients planned to undergo coronary angiography [CAG] in order to find a simple, cost-benefit, noninvasive way, for ruling in/out obstructive CAD. In a cross sectional study in Imam Khomeini hospital in 1390, CACS by using non-enhanced multi detector computed tomography [MDCT] and measurement of serum level of PTH, Calcium and Phosphate were done in 178 patients suspected to CAD which were scheduled to undergo coronary angiography serum PTH was measured by immuno-radiometric assay [IRMA] and serum Ca and Phosphate were measured by spectrophotometry methods. Of 178 Patients, 50 patients were females and 126 patients were male. Mean age of them was 56.2 +/- 11.6. The correlation coefficient between CACS and Gensini score [0.507, P<0.001], PTH [0.037, P=0.693], Ca [0.062, P=0.499] and Phosphate [0.061, P=0.506] were obtained. The level of serum PTH in the patients with and without coronary artery disease were 21.8 +/- 11.6 pg/dl, 23.2 +/- 11.5 pg/dl [P=0.427] respectively. Our study showed association between CACS and CAD that was statistically significant while no relationship was found between PTH, CACS and CAD.