[Association between oxidative stress parameters and inflammations markers according to the gravityt of the acute coronary syndrome]

ABSTRACT

Cardiovascular disease is the consequence of appearance and development of atherosclerosis lesions of associated with a inflammatory complication. To elucidate a possible association between several inflammation and oxidative stress markers according to the severity of coronary artery disease. This study was carried on 93 coronary subjects with unstable angina [UA; n=42]; stable angina [SA; n=15] and acute myocardial infarction [AMI; n=36] and 140 control subjects to whom lipidic, oxidative and inflammatory parameters were determined. In addition to a moderate hyperhomocysteinemia observed in the coronary artery disease, a significant higher levels of the oxidized LDL [ox-LDL] were found among these patients [p< 0.001]. A positive correlation was found between the markers of the inflammation and the gravity of the acute coronary syndrome. One note a significant increase of the rate of ox-LDL and high sensitive CRP to AMI by reports in UA and SA [p=0.00, and p=0.001 respectively] which is linked to an elevation of the plasmatic concentration of the total homocysteine. This study suggests an association between the markers of the inflammation and oxidative parameters in the acute coronary syndrome