[Biological diagnosis of haemophilia]

ABSTRACT

It is a constitutional hemorrhagic disease of recessive transmission linked to X chromosome. Our objective work is to index the different cases in our service. During 18 months [April 2008 - September 2009], we account 124 haemophiliac cases diagnosed in our laboratory. Our results interest a diagnosed 124 haemophiliac cases, including 99 cases of haemophilia A [79, 83%] and 25 cases of haemophilia B [20,17%]. 81 patients have an age less than 15 years old with a median of age as 13 years [limits 9 months - 39 years]. The annual incidence of haemophilia is 82 cases. 62 persons had clinical symptomatology whereas the others were asymptomatic. These symptoms were arthropathy [59, 67%], haemoarthrosis [27,4%], haematoma [4,83%], nosebleeds epistaxis, gingivorrhagia gums [4,83%] and ecchymosis [3,26%]. According to the type of haemophilia. The severe forms of haemophilia [FVIII of FIX haemophilia A and 64% [16/25] for haemophiliaB. The diagnosis and classification of the haemophilia are possible in routine examination. Through the data of literature we propose a diagnostic strategy which makes it possible to consolidate the analysis of the constitutional haemostasis hemorrhagic diseases in particular of the haemophilia. The medical care of the haemophilia starts with the diagnostic stage. Our hope is to be able to extrapolate this study at the natural level to set up a national file