Ocular toxicity and histopathological study of ethanol in albino rats

ABSTRACT

The histopathological effects of ethanol toxicity on the eyes of albino rats were studied in three different stages acute [received acute toxic dose LD50], subacute and short term chronic intoxication [received 1/10 of the LD50]. The results showed oedema of the optic nerve and retina associated with vascular dilatation and congestion in the acute and subacute toxicity, while degeneration of the inner granular cell layer, nerve fibers associated with thickening of supporting tissues, internal limiting membrane and central retinal artery were observed in chronic toxicity