Pharmacological bases of pyogenic brain abscesses antibiotherapy

ABSTRACT

The adequate treatment of cerebral abscesses implicates a rapid start-up of an adapted antibiotherapy. Specific properties characterizing cerebral parenchyma, in particular the low level of its local defences and the presence of a blood-brain barrier limiting diffusion of several antibiotics, imply a perfect control of the antibiotherapy bases. Activity on the micro-organisms involved, bactericidal action, easy diffusion through the blood-brain barrier and the wall of the abscess, as well as conservation of a good activity in the pus are the principal criteria of the treatment. The real intra cerebral activity of antibiotics remains difficult to evaluate because of the ethical obstacles which block such evaluations