Significance of grade in relation to oestrogen receptor status and Ki-67 proliferative index in cancer breast
Biomedica. 2009; 25 (Jul.-Dec.): 116-119
in English
| IMEMR
| ID: emr-134456
ABSTRACT
The objective of this study was to determine the relationship between oestrogeu receptor [ER] status and Ki-67 proliferation index in relation to age of the patients, grade, size of tumours and lymph node involvement in carcinoma of the breast in a local population. It is a cross-sectional and descriptive study. The study was conducted during a period of 12 months in the Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore. A total of 100 cases of carcinoma of the breast were collected and immunohistochemistry was carried out on all the tumours. Statistical analysis was performed by using SPSS 16. A significant inverse correlation between ER and grade of tumours was observed with a p-value being < 0.005 and r value of -0.281. As a conclusion it was found that ER and grade of tumours had significant inverse correlation, whereas there was no significant correlation between Ki-67 proliferative index and grade of tumours. It was also concluded that there was no significance of age of the patients, tumour size and lymph node involvement
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunohistochemistry
/
Receptors, Estrogen
/
Cross-Sectional Studies
/
Ki-67 Antigen
/
Lymph Nodes
/
Neoplasm Staging
Type of study:
Prevalence study
Limits:
Female
/
Humans
Language:
English
Journal:
Biomedica
Year:
2009
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