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[Relaxing effect of achillea: detect the effect and the mechanism on isolated aortic rings]
Arab Journal of Pharmaceutical Sciences. 2009; 4 (1): 31-41
in Arabic | IMEMR | ID: emr-134513
ABSTRACT
The vasodilator effect of Achilea was investigated using isolated rabbit aortic rings. Both ethanolic and aqueous extracts have shown a profound relaxing effect on phenyl ephrine-precontracted aortic rings. There was no difference in the effect in the absence or presence of endothelium. Anyway, the ethanolic extract was obviously more potent than aqueous and therefore it was then chosen to continue the study to investigate the role of potassium channels. The K+ channels blockers, Glibenclamide and TEA, partially inhibited the relaxing effect of Achillea. On the other side, the ethanolic extract has also shown a relaxing effect on aortic rings precontracted by high concentration of K[+] ions [35mM]. These data clearly indicate that relaxing effect of Achillea is not endothelium-dependent but it is related to K+ channels
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Index: IMEMR (Eastern Mediterranean) Main subject: Aorta / Rabbits / Relaxation / Plant Extracts / Ethanol Limits: Animals Language: Arabic Journal: Arab J. Pharm. Sci. Year: 2009

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Index: IMEMR (Eastern Mediterranean) Main subject: Aorta / Rabbits / Relaxation / Plant Extracts / Ethanol Limits: Animals Language: Arabic Journal: Arab J. Pharm. Sci. Year: 2009