[Lupus nephritis and pregnancies about 43 cases]

ABSTRACT

In lupus nephritis, pregancies can be associated with worsening of nephropathy and several other maternal and foetal complications. We analyzed in this retrospective study on a period of 30 years, maternal and fetal outcome of 43 pregancies occuring in 21 women treated for lupus nephritis. Pregnancies were sudivided in 2 groups G1 including 17 pgnancies that underwent with proteinuria>1g/24 hours and/or high blood pressure and/or creatinemia>140 micro mol. G2 including 26 pregnancies underwent in absence of all these factors during at least 3 months. Renal flares occured in 17 pregnancies [G1 34, 6%NS] with renal function impairement in II cases [G1 41, 7%, G215, 3%, p 0, 01] and preeclampsia in 14 pregnancies [G157, 3%, G2 42, 7%NS]. Fetal loss occured in 8 cases [G1 29, 4%G2 11%, p=0, 01]. Among live births there were 17 preterm deliveries [G1 62%, G2 63%NS]. We found that pregnant women with Iupus nephritis remain at high risk of relapses and prematurity. Renal function impairement and fetal loss are more freqnent when lupus nephritis is active at conception. Close monitoring of these patients and planification of pregnancies reduces these complications