Are JLA DQB1 alleles correlated with breast cancer histoprognostic parameteres in Tunisia?

ABSTRACT

Tumor cells express surface structures different from normal cells. These structures may be recognized by the immune system, which ensure anti-tumoral surveillance. Antigenic presentation requires HLA molecules role. Since, these molecules are encoded by a high polymorphic system, immune response can be modulated according to HLA genotype. So, HLA polymorphism could be correlated with tumor escape from anti-tumor immunosurveillance. We have aimed to search for possible associations between HLA DQB 1 alleles and the histoprognostical parameters in breast cancer in the Tunisian population. DQB 1 alleles were determined by PCR-SSO molecular typing in 100 healthy matched and unrelated Tunisian female and 87 Tunisian women with breast cancer. Allelic distribution between the two studied groups showed no significant associations between this locus and the occurrence, the EE grade and the lymph node invasion of breast cancer in the Tunisian population. This result may be explained by the fact that cancer is a multifactoral disease due to several interacting factors that might change from one population to another