histological study of the effects of nonsteroidal antiinflammatory drugs [NSAIDs] on the gastric and duodenal mucosa

ABSTRACT

The effect of nonsteroidal anti-inflammatory drugs [NSAIDs] on the gastric and duodenal mucosa was studied in 53 patients. On endoscopic biopsies, 87% patients showed gastritis and 90% duodenitis. Chronic superficial gastritis was the most frequent lesion in the stomach [49%]; and mild duodenitis in the duodenum [54%]. The antrum was the most frequently involved site in the stomach. An interesting finding in cases of duodenitis was the presence of dilated intestinal glands plugged with mucus