Study of some minerals, trace elements and antioxidants in refractory childhood epilepsy
Alexandria Journal of Pediatrics. 2011; 25 (1): 23-28
in English
| IMEMR
| ID: emr-135632
ABSTRACT
The aim of this study is to evaluate the role of some minerals, trace elements and anti-oxidants in children with intractable epilepsy compared to healthy children. In a case control study, 45 epileptic patients [24 male and 21 female] with age range between 3 to 14.5 years presented to Assiut pediatric university hospital, suffering from various types of refractory epileptic seizures compared with 20 healthy sex- and age-matched children served as controls. Serum Se, Zn, Cu, Mg, Glutathione peroxidase [GSH-PX] and Superoxide dismutase [SOD] were measured. The mean age of the patients +/- SD was 8.4 +/- 3.1y. The serum levels of Zn, Mg and Se are significant lower in patients in comparison with control, p value < 0.001 for each, with no significant difference between both groups in serum Cu. Glutathione peroxidase [GSH-PX] was significantly lower in patients in comparison with control group [p value < 0.001] with no significant difference between both groups in SOD. Some minerals [Mg], trace elements [Zn, Se] and antioxidants [GSHúPX] may play an important role in the pathogenesis of intractable epilepsy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Selenium
/
Superoxide Dismutase
/
Trace Elements
/
Zinc
/
Child
/
Glutathione Peroxidase
/
Magnesium
/
Minerals
/
Antioxidants
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Alex. J. Pediatr.
Year:
2011
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