Utility of hydrazonoyl halides as precursors for synthesis of novel antitumor pyrazolo [3,4-d] pyrimidine derivatives
Egyptian Journal of Chemistry. 2009; 52 (2): 265-275
in English
| IMEMR
| ID: emr-135672
ABSTRACT
Novel substituted pyrazolo[3,4-d]pyrimidine-4,6-dione [5a-j] have been prepared by reacting 1,3-dimethylbarbituric acid 1 with hydrazonoyl chloride [2a-j].The cytotoxicity [SRB assay using tumor cells] of compounds 5c,e against liver [HEPG2] and breast carcinoma [MCF7] cell lines revealed that 5c was more efficient than the standard drug [Doxorubicin]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pyrimidines
/
Antineoplastic Agents
Language:
English
Journal:
Egypt. J. Chem.
Year:
2009
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