Preoperative diagnosis of ovarian cancer in patients presented with adnexal mass using the risk of malignancy index

ABSTRACT

To detect ovarian cancer in patients presented with adnexal mass using Risk of Malignancy Index [RMI] based on menopausal status, ultrasound findings and serum level of CA125. Setting AI-Hussein University Hospital, Cairo- Egypt. Participants one hundred and forty women, 30 years or older, admitted with adnexal mass between September 1998 and February 2002, for laparotomy. Main Outcome Measures the sensitivity, specificity and positive predictive value of RMI based on menopausal status, ultrasound findings and serum CA 125 to diagnose ovarian cancer patients. Results using a cut-off level of 200 to indicate malignancy, the RMI gave sensitivity of 86.67%, specificity of 92.5% and positive predictive value of 89.66%. The risk of malignancy index is able to correctly discriminate between malignant and benign adnexal mass. It is highly recommended to be introduced into clinical practice in Egypt to facilitate the selection of patients for primary surgery at an Gynecologic Oncology Unit