Umbilical cord blood leptin, insulin -like growth factor-1, insulin -like growth factor binding protein-3 and newborn birth weight in pre-eclampsia

ABSTRACT

The aim of this study was to determine whether newborn birth weight is correlated to IGF-1, IGFBP-3 and leptin in cases with moderate preeclampsia. This study was done cross-sectionallly and included 25 pregnant women with moderate preeclampsia [PE group] and 25 normotensive pregnant women [NT group] of similar gestational age. Umbilical cord blood levels of IGF-1, IGFBP-3 and Leptin were assessed in each group. As compared with the NT group the PE group had significantly [p<0.001] lower newborn birth weight [3.33 [ +/- 0.9] vs 2.8 [ +/- 0.7] kg]], IGF-1 [66.5 [ +/- 26.7] vs 29.5 [ +/- 14.8] ng / ml] and IGFBP-3 [1250 [ +/- 39.94] vs 911 [ +/- 63.7] ng / ml]. Leptin was shown to be significantly [p<0.001] higher in the PE group compared with NT group. Significant correlation [r=0. 79, p<0.0001] was found between serum cord IGF and newborn birth weight, using stepwise multiple regression analysis, newborn birth weight was predicted by umbilical IGF-1 [r=0.53, p<0.0001]. A significant correlation between cord blood leptin and newborn birth weight was found only in the PE group r= 0.5 [p<0.01].No differences was found among female and male newborns regarding umbilical cord leptin concentration. The present study indicates that moderate preeclampsia is associated with low birth weight. IGF-1, IGFBP-3 and high leptin levels. There was a correlation between birth weight and IGF-1 which can predict newborn birth weight. Correlation between umbilical cord leptin and birth weight was found in cases with preeclampsia with no differences between leptin levels among female and male newborns