Comparison of low dose intraoperative mitomycin C, postoperative mitomycin C drops and conjunctival autograft in primary pterygium

ABSTRACT

Comparison the safety and efficacy of low dose intraoperative MMC [0.02%], postoperative MMC [0.02%] drops and conjunctival autograft transplantation were done on 48 eyes of 39 patients with primary pterygium. Their age ranged from 21 to 68 years, they were 29 males and 10 females. All patients underwent complete ophthalmological examination including visual acuity, slit lamp biomicroscopy of anterior segment. Patients divided into 3 groups after excision of pterygium. Group I 16 eyes with intraoperative MMC [0.02%]. Group II 15 eyes with postoperative MMC drops [0.02%]. Group III 17 eyes with application of conjunctival graft. Follow up period ranged from 8-15 months [mean +/- SD 10 +/- 3.2 years]. In eyes treated with intraoperatival MMC, 2 eyes [12.5%] had delayed epithelial defects and recurrence occurred in one eye [6.25%]. In eyes treated with postoperative MMC drops, 3 eyes [20%] had punctate keratitis, delayed epithelial defect observed in one eye [6.6%] and recurrence occurred in one eye [6.6%]. In eyes treated with conjunctival autograft transplantation, 4 eyes [23.52%] had graft oedema, 2 eyes [11.76%] had wound dehiscence, granuloma was seen in one eye [5.88%] and recurrence occurred in one eye [5.88%]. Intraoperative low dose of MMC [0.02%], postoperative MMC drops [0.02%], and conjunctival autograft transplantation are equally effective as adjunctive treatment to primary pterygium with no statistical difference in recurrence rates and neither associated with severe complications