Effect of calcium antagonists on kidney function in rats

ABSTRACT

Calcium antagonists is cardiovascular protective drugs and used in treatment of hypertension in addition to its nephroprotective effect. The present work was carried out on thirty male albino rats which divided into three equal groups. Group I it included 10 normal rats used as control. Group II it included 10 induced acute uraemic rats by dehydration for 24 hours then intramuscular injection 10 mg/kg glycerol. Group III it included 10 induced uraemic rats received diltiazem 9 mg/kg twice daily orally 7 days before dehydration. Our results showed that the biochemical parameters [urea, creatinine, sodium, potassium] was significantly increased in group II as compared to normal rats as a result of dehydration and glycerol injection in this group. On other hand the mean value of biochemical parameters of kidney function in group III that received diltiazem was significantly decreased in comparison to group II but there is no significant difference in the parameters of kidney function between group III and group I. Calcium antagonists showed nephroprotective effect. The above results suggest the possiblity of using diltiazem in treatment of acute renal failure or as a prophylactic when acute renal failure is predicted