Comparison of tuberculin skin test result and interferon gamma response to human PPD in BCG scar positive and negative children
Journal of Epidemiology and Global Health. 2014; 4 (1): 45-50
in English
| IMEMR
| ID: emr-136480
ABSTRACT
The aim of this study is to compare Tuberculin Skin Test [TST] result and interferon gamma response to human PPD [purified protein derivative], in scar positive and scar negative BCG-vaccinated children. Between August 2007 and May 2008 a total of 236 children aged 1-168 months [mean 21 months] admitted to Mofid Children's Hospital, Tehran, Iran, were enrolled in a cross-sectional study. Each patient was examined for BCG vaccine scar and tested with TST and human PPD-based Interferon Gamma Release Assay [IGRA]. Two hundred and twenty one cases out of 236 [44% female, 1-168 months, mean age 21 months] were scar positive of whom 95% TST result was negative. Human PPD-based IGRA was positive in 110 [49.8%], negative in 85 [38.4%] and indeterminate in 26 [11.8%] of scar positive patients. Fifteen children [40% female, 1-156 months; mean age 42 months] were scar negative. All the scar negative cases were TST negative. Human PPD-based IGRA was positive in 10 [66.7%], negative in 4 [26.7%] and indeterminate in 1 [6.7%] of scar negative patients. Immune responsiveness to human PPD antigens in scar positive and negative children may not correspond with results of the Tuberculin Skin Test
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
J. Epidemiol. Glob. Health
Year:
2014
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