Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and dna damage on rat uterus tissue

ABSTRACT

In this study, we investigated the effects of treatment with chronic antihypertensive drugs [clonidine, methyldopa, amlodipine, ramipril and rilmenidine] on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. A total of 36 albino Wistar rats were divided into the following six groups 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test. We divided these drugs into the following three groups according to their effects on rat uteri [I] mild negative effects [clonidine], [II] moderate negative effects [rilmenidine, methyldopa] and [III] drugs which had severe negative effects [amlodipine, ramipril]. These data may help with selection of antihypertensive drugs, in order to determine which drugs have the lowest toxicity in pregnant and non-pregnant [pre-pregnancy] women