Association of vitamin D receptor polymorphism [VDR rs 2238136] with colorectal cancer
Journal of Kerman University of Medical Sciences. 2012; 19 (1): 1-8
in Persian
| IMEMR
| ID: emr-137416
ABSTRACT
Many studies have demonstrated that Vitamin D has an important role in cell growth and proliferation and vitamin D receptor polymorphism has significant relationship with colorectal cancer [CRC]. The aim of this study was to assess the incidence of VDR rs 2238136 polymorphism in Iranian population and to investigate the relationship between this single nucleotide polymorphism [SNP] and increased risk of CRC. In this case-control study, genotyping of vitamin D receptor gene polymorphism [VDR rs2238136] was determined in a series of 112 colorectal cancer patients and 112 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays [PCR-RFLP]. Statistical analysis was done through SPSS 16. VDR polymorphism [rs 2238136] had no significant relationship with CRC risk. The result of statistical analysis for the genotype AG compared with GG was OR=0. 59, CI=0.33-1.03 and for AA versus GG was OR=0.8, Ct=0.29-2.17. Incidence of mutant allele in patients and controls did not show significant difference [OR=0.74, CI=0.49 -1.13]. These findings suggest that VDR [rs 2238136] is not associated with increased risk of CRC. Moreover age, sex and smoking are not predisposing factors for increased risk of CRC
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polymorphism, Genetic
/
Vitamin D
/
Polymorphism, Restriction Fragment Length
/
Colorectal Neoplasms
/
Case-Control Studies
/
Polymerase Chain Reaction
/
Risk Factors
/
Genetic Predisposition to Disease
/
Genotype
Limits:
Humans
Language:
Persian
Journal:
J. Kerman Univ. Med. Sci.
Year:
2012
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