Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea

Agung Endro, Nugroho; Yance, Anas; Puguh Novi, Arsito; Joko Tri, Wibowo; Sugeng, Riyanto; Mohamad Aspollah, Sukari

Agung Endro, Nugroho; Yance, Anas; Puguh Novi, Arsito; Joko Tri, Wibowo; Sugeng, Riyanto; Mohamad Aspollah, Sukari.

Pakistan Journal of Pharmaceutical Sciences. 2011; 24 (4): 427-433

in English | IMEMR | ID: emr-137540

ABSTRACT

ABSTRACT

Marmin or 7-[6', 7'-dihydroxygeranyl-oxy] coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evaluated its action against contraction induced by extracellular or intracellular calcium ion. The possibility of marmin to potentiate the

Subject(s)

Animals, Laboratory; Male; Aegle/chemistry; Coumarins/isolation & purification; Trachea/drug effects; p-Methoxy-N-methylphenethylamine/pharmacology; Muscle, Smooth/drug effects; Muscle Relaxation/drug effects; Muscle Contraction/drug effects; Guinea Pigs

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Index: IMEMR (Eastern Mediterranean) Main subject: Trachea / P-Methoxy-N-methylphenethylamine / Coumarins / Aegle / Guinea Pigs / Muscle Contraction / Muscle Relaxation / Muscle, Smooth Limits: Animals Language: English Journal: Pak. J. Pharm. Sci. Year: 2011

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