Some immunological profile of rheumatoid arthritis

ABSTRACT

Seventy- four cases of clinically diagnosed Rheumatoid Arthritis [RA], fifty cases of systemic lupus erythematosus [SLE], and thirty healthy normal controls "were investigated for detection of rheumatoid factor [RF], total serum immunoglobulins [Igs], antinuclear antibody [ANA], and ANA subtype anti-double stranded DNA [anti-ds DNA], Patients with RA showed 58.1% positive for RF comparable with 14% positivity in SLE patients and 6.6% in normal individuals. Serum Igs [IgA,IgG] were found to be elevated in RA and SLE patients [62.2%, 36.5%] [54%, 38%] respectively. This study revealed that ANA is found in 88% of SLE patients sera and 78% of these ANA is ds DNA in comparison with only 6.8% of RA sera were found positive for ANA