[Effect of oral vitamin c on anemia, uremia and blood pressure in patients with chronic renal failure receiving hemodialysis]

ABSTRACT

Vitamin C deficiency is a common in hemodialysis patients. Evidences indicated that oxidative stress is associated with Vitamin C deficiency. Oxidative stress plays an important role in the progression of anemia, uremia and hypertension in the patients with chronic renal failure that receiving hemodialysis. The purpose of this study was to determine the vitamin C effects on systolic blood pressure, hemoglobin, hematocrit, blood urea and creatinine. In a randomized clinical trials with registry number IRCT2387 in Emam Reza and Besat University Hospitals in 2009, fifty six hemodialysis patients who met the inclusion criteria were selected by simple randomization method. These subjects were divided in two groups randomly The experimental group who received oral vitamin C 250 mg, three times per week until two months. The amounts of blood pressure, hemoglobin, hematocrit, blood urea and creatinine tests were compared before and after the intervention. Finally the results were analyzed statically with T test by considered P-value less than 0.05. The level of hemoglobin and blood pressure was higher in experimental compared to control not significantly. While the blood urea and creatinine was insignificantly lower after intervention. These results show a statistical significance difference due to increasing of hematocrit level by using of oral vitamin C [P<0.05]. There is association between supplementation with oral vitamin C in hemodialysis patient and systolic blood pressure, hemoglobin, hematocrit, blood urea and creatinine. Therefore further studies are needed to determine the clinical benefits of antioxidants interventions in hemodialysis patients