Pregabalin in muscular cramps [charely hoarse] a new application

ABSTRACT

Pregabalin is a newly introduced medicine which is an analogue to Gaba pentin and similar to its structure, it was approved by the FDA in 2004 and marketed by Pfizer company under the name of LARYICA. It has been described in various medical disorders among which are neuropathic pain as that of diabetes [1,2], post herpetic neuralgia [3], seizure disorders [4] and anxiety state [5]. Pregabalin the first medicine approved for treatment of fibromyalgia by the FDA [6,7] Pharmacologically Pregabalin bind to alpha 2 delta subunit of the voltage-dependent calcium channels in the central nervous system, it also decrease the releases neurotransmitters such as glutamate, noradrenalin and the substance P [8,9]. Though FDA label indications are; diabetic peripheral neuropathy, fibromyalgia, Post herpetic neuralgia and as an adjunct in seizure, yet Pregabalin have been Used in many other conditions on empirical bases as a treatment of a single case Or more as in post operative Pain [10] or hot flash [11] beside other diseases. Herewith I am reporting an unusual clinical observation never been described before, the Night Muscular cramps in the Legs collegially known as "Charley hoarse" known by Iraqis as "ABU SLSHERGATE"