[ effect of local pentoxifylline in prevention of abdominal adhesion after laparotomy in rat models]

ABSTRACT

The aim of this study was to investigate the role of local pentoxifylline in reducing peritoneal adhesions after laparotomy performed on rats. In this randomized double-blind study, 30 male white rats weighing approximately 280-300 g were divided into two equal groups. In the control group, after induction of anesthesia and under sterile conditions, with a midline incision of 3 cm the muscles and the peritoneum opened. Animal cecum was determined by the surgeon and with one gauge, abrasions were made on antimesentric edge of cecum. Then the cecum was placed back in the abdomen and the abdomen was closed in 2 layers using nylon string "2-0" and running sutures. In case group all the above steps were repeated. The abdomen was washed with local pentoxifylline. After 2 weeks, rats were re- laparotomy. Blasting locations were studied in a previous surgery and adhesion were recorded from 0 to 3. And finally the data were analyzed by SPSS v.11 software using of statistical tests. In all of control group, adhesion was founded. In case group adhesions were founded in seven cases. Adhesion rate difference between the two groups was significant [P=0.013]. According to obtained findings from this and other similar studies, the surgeons can reduced adhesions after abdominal surgery by using local pentoxifylline