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Suppressive effects of Rosa damascena essential oil on naloxone-precipitated morphine withdrawal signs in male mice
IJPR-Iranian Journal of Pharmaceutical Research. 2013; 12 (3): 357-361
in English | IMEMR | ID: emr-138292
ABSTRACT
This research was done to test the effect of Rosa damascena essential oil on withdrawal signs of naloxone-precipitated morphine in male mice. Morphine dependence was induced by injection [IP] three times daily at doses of 50, 50 and 75 mg/kg, respectively, for 3 days. On day 4, after the last administration of morphine, Rosa damascena essential oil was administered at different concentrations [5, 2 and 40%, IP] 30 min before administration of naloxone [5 mg/kg, IP]. The following actions were taken as signs of withdrawal and records taken for jumping as a number and scores of 0 to 3 were given for incidences of grooming, teeth chattering, rearing, writing, diarrhea, wet dog shakes and climbing during a 30 min period. Results showed that different concentrations of Rosa damascena essential oil significantly reduced signs of morphine withdrawal compared to the control group in terms of number of jumps [p < 0.05 and p < 0.01], grooming, teeth chattering, rearing, climbing, wet dog shakes and writhing, but not for diarrhea [p < 0.05]. In conclusion it seems that GABAergic activity induced by flavonoids from Rosa damascena essential oil can alleviate signs of morphine withdrawal, but further studies need to be done to better understand this mechanism
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Index: IMEMR (Eastern Mediterranean) Main subject: Substance Withdrawal Syndrome / Behavior, Animal / Substance-Related Disorders / Analgesics, Opioid / Mice / Morphine Dependence / Naloxone Limits: Animals Language: English Journal: Iran. J. Pharm. Res. Year: 2013

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Index: IMEMR (Eastern Mediterranean) Main subject: Substance Withdrawal Syndrome / Behavior, Animal / Substance-Related Disorders / Analgesics, Opioid / Mice / Morphine Dependence / Naloxone Limits: Animals Language: English Journal: Iran. J. Pharm. Res. Year: 2013