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Endothelium-dependent effect of sesame seed feeding on vascular reactivity of streptozotocin-diabetic rats: underlying mechanisms
IJPR-Iranian Journal of Pharmaceutical Research. 2013; 12 (3): 377-385
in English | IMEMR | ID: emr-138295
ABSTRACT
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of sesame [Sesamum indicum L] seed feeding was studied on aortic reactivity of streptozotocin [STZ]-diabetic rats. Male diabetic rats received sesame seed-mixed food at weight ratios of 3% and 6% for 7 weeks, one week after diabetes induction. Contractile responses to KCl and phenylephrine [PE] and relaxation response to acetylcholine [ACh] and sodium nitroprusside [SNP] were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to PE was significantly lower in sesame-treated diabetic rats [at a ratio of 6%] relative to untreated diabetics and endothelium removal abolished this difference. Endothelium-dependent relaxation to ACh was also significantly higher in sesame-treated diabetic rats [at a ratio of 6%] as compared to diabetic rats and pretreatment of rings with nitric oxide synthase inhibitor, N[G]-nitro-l-arginine methyl ester [L-NAME] significantly attenuated the observed response. Two-month diabetes also resulted in an elevation of malondialdehyde [MDA] and decreased superoxide dismutase [SOD] activity and sesame treatment significantly reversed the increased MDA content and restored activity of SOD. We thus conclude that chronic treatment of diabetic rats with sesame seed could in a dose- manner prevent some abnormal changes in vascular reactivity through nitric oxide and via attenuation of oxidative stress in aortic tissue and endothelium integrity is necessary for this beneficial effect
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Index: IMEMR (Eastern Mediterranean) Main subject: Superoxide Dismutase / Rats, Wistar / Nitric Oxide Synthase / NG-Nitroarginine Methyl Ester / Diabetes Mellitus, Experimental / Endothelium / Muscle, Smooth, Vascular Limits: Animals Language: English Journal: Iran. J. Pharm. Res. Year: 2013

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Index: IMEMR (Eastern Mediterranean) Main subject: Superoxide Dismutase / Rats, Wistar / Nitric Oxide Synthase / NG-Nitroarginine Methyl Ester / Diabetes Mellitus, Experimental / Endothelium / Muscle, Smooth, Vascular Limits: Animals Language: English Journal: Iran. J. Pharm. Res. Year: 2013