Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, Radix scutellariae and Scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats
IJPR-Iranian Journal of Pharmaceutical Research. 2013; 12 (3): 399-409
in English
| IMEMR
| ID: emr-138297
ABSTRACT
The aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. The plasma concentrations of the four flavonoids were determined by using a simple and rapid high-performance liquid chromatography method. All the rats were divided randomly into two groups [ulcerative colitis and normal groups]. Each group contained three subgroups pure baicalin, Radix scutellariae and Scutellariae-paeoniae couple extracts subgroup. Each group received oral administration of pure baicalin, Radix scutellariae and Scutellariae-paeoniae couple extracts at the same dose of 200 mg/kg baicalin. The results showed that wogonoside, possibily as a methylated product of baicalin, was found in plasma after oral administration of pure baicalin or formulas to rats. Baicalin and wogonoside demonstrated bimodal phenomenon. Baicalin and wogonoside in Scutellariae-Paeoniae couple extract had shown better absorption than which inpure baicalin and Radix scutellariae extract. Whether oral administration of pure baicalin, Radix Scutellariae or Scutellariae-paeoniae couple extracts, ulcerative colitis rats showed better absorption than normal rats. For example AUC[0-t] of baicalin were [41.46 +/- 0.62], [59.12 +/- 6.42] and [104.87 +/- 0.86] [micro g/mL] h in UC groups vs [17.77 +/- 0.66], [28.04 +/- 4.06] and [49.01 +/- 4.61] [micro g/mL] h in normal groups, respectively. The pharmacokinetics properties of the four flavonoids differed between ulcerative colitis and normal rats, including AUC[0-t] and C[max] [p < 0.05]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Drugs, Chinese Herbal
/
Plant Extracts
/
Colitis, Ulcerative
/
Administration, Oral
/
Chromatography, Liquid
/
Rats, Sprague-Dawley
/
Scutellaria
/
Flavanones
/
Glucosides
Limits:
Animals
Language:
English
Journal:
Iran. J. Pharm. Res.
Year:
2013
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