Immunoglobulin a nephropathy and malaria falciparum infection; a rare association
Iranian Journal of Public Health. 2013; 42 (5): 529-533
in English
| IMEMR
| ID: emr-138372
ABSTRACT
Glomerular involvement occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Here, we report a rare case of falciparum malaria-associated IgA nephropathy. A 28-year-old man was admitted because of fever and abdominal pain. Ultrasound and computed tomography [CT] showed right kidney pyonenphrosis. Despite placing a nephrostomy tube, fever continued. Repeated CT was in favor of focal pyelonephritis. In addition, peripheral blood smear suggested malaria. Anti-malarial drugs were initiated and right nephrectomy was performed. One year after recovery from malaria, a persistent rise in serum creatinine was detected. A left kidney biopsy showed mesangial proliferation and dominant IgA deposits in immunofluorescence study while C[1q] was not deposited. The impression was IgA nephropathy with M[1]E[0]S[0]T[0] of Oxford classification. The patient was prescribed a combination of low dose prednisolone and angiotensin converting enzyme inhibitor. Six months after treatment serum creatinine decreased from 1.6 mg/dL to 1.3mg/dL and urine abnormalities were disappeared. Our findings suggest that malaria infection might be associated with IgA nephropathy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Plasmodium falciparum
/
Immunoglobulin A
/
Fluorescent Antibody Technique
/
Glomerulonephritis, IGA
Type of study:
Case report
Limits:
Humans
/
Male
Language:
English
Journal:
Iran. J. Public Health
Year:
2013
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