Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N omega -Nitro-L-arginine methyl ester

ABSTRACT

This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by N [omega] -Nitro-L-arginine methyl ester [L-NAME]. Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased [P<0.05]. The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased [P<0.05]. L-NAME caused increase [P<0.05] in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased [P<0.05], platelets and lymphocyte increased [P<0.05] in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide