QT dispersion increases with low glomerular filtration rate in patients with coronary artery disease

ABSTRACT

We aimed to evaluate the relationship between estimated glomerular filtration rate [eGFR] and QT dispersion [QTd] in patients with coronary artery disease [CAD]. Sixty patients [mean age 62.72 +/- 12.48 years] included 46 male, [mean age 60.89 +/- 12.70 years] and 14 female [mean age 68.71 +/- 9.86 years] were enrolled in this study. Patients were divided into 2 groups according to their eGFR using the 6 variable MDRD equation. Group 1 consisted of patients with estimated eGFR < 60 ml/min/1.73m[2] and Group 2 consisted of patients with eGFR >/= 60 ml/min/1.73m[2]. Baseline patient characteristics were homogeneous in both groups except for age, gender and smoking. Also, the extent of CAD was similar in both groups [p > 0.05] QTd values were found higher in group 1 than those of group 2 [57.23 +/- 40.65 ms vs. 31.23 +/- 14.47 ms, p = 0.002]. After adjustment for age, gender and smoking using one-way ANCOVA test, statistically significant difference in QTd still existed between the groups [p=0.038]. QTd tends to be higher in patients with poor renal function independent of severity of angiographical CAD. QTd may be a potentially useful non-invasive test in the management of patients with poor renal function, especially those with CAD