Effects of low-dose amiodarone and Betaloc on the treatment of hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmias

ABSTRACT

To study the therapeutic effects of low-dose amiodarone and Betaloc on hypertrophic cardiomyopathy complicated by malignant ventricular arrhythmias. Eighty-two such patients were selected and divided into a treatment group and a control group by the random number method [n=41], which were administered with low-dose amiodarone plus Betaloc and individual Betaloc respectively. The treatment group had a significantly higher overall effective rate [85.4%] than the control group [65.9%] did. Based on the New York Heart Association's classification of cardiovascular disease, the treatment group mainly comprised Class III and IV patients before treatment, which were significantly relieved after treatment [P < 0.05]. The heart rate was evidently decreased from [119.99 +/- 18.91] bpm to [80.98 +/- 12.34] bpm, and the incidences of premature ventricular contraction and tachycardia were significantly reduced [P < 0.05]. The longest QT intervals after and before treatment were [421 +/- 32] ms and [411 +/- 35] ms respectively. The shortest QT interval after treatment [[350 +/- 36] ms] was significantly longer than that before [[307 +/- 31] ms]. The QT dispersion before treatment [[96 +/- 29] ms] was significantly higher that after [[64 +/- 17] ms] [P < 0.05]. Six out of eighty two patients in the treatment group succumbed to adverse reactions [14.63%]. Hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmias can be well treated with low-dose amiodarone and Betaloc, with mitigated symptoms, improved prognosis and few adverse reactions