Synthesis, characterization and enzyme inhibition study of O-substituted derivatives of chlorinated coumarin
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (2): 271-278
in English
| IMEMR
| ID: emr-138625
ABSTRACT
Coumarins have much importance in dyes, drugs, perfumes and pesticides. In the demonstrated research work, a benignant series of chlorinated coumarins was synthesized and screened against different enzymes. First, 6-Chloro-7-hydroxy-4-methyl-2H-chromen-2-one [3] was geared up by the reaction of 4-chlororesorcinol [1] and ethyl acetoacetate [2] in the presence of concentrated H[2]SO[4]. Second, various O-substituted derivatives of chlorinated coumarins, 5a-j, were set up by pairing different alkyl/aralkyl halides, 4a-j, with 3 in the presence of NaH in DMF as solvent. The structures of all the synthesized compounds were clarified through spectral analysis using EI-MS, IR and [1]H-NMR. The different enzymes used for the evaluation of bioactivity of all the synthesized compounds were acetyl cholinesterase [AChE], butyryl cholinesterase [BChE] and lipoxygenase [LOX]. The most proficient activity was shown against both cholinesterase enzymes
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2014
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