Serum lipid profile; significance of risk factors regarding offsprings of premature coronary heart disease patients

ABSTRACT

This study was conducted to determine serum lipid profile in children of premature coronary heart disease patients and compare results between children having parents with one, two or three risk factors. A cross sectional comparative study. Ninety seven [97] subjects having parents with one risk factor, sixty three [63] subjects having parents with two risk factors and sixty five [65] subjects having parents with three risk factors were selected from Punjab Institute of Cardiology Lahore. Fifty [50] age and sex matched subjects of parents without a history of coronary heart disease were also selected. The serum total cholesterol, serum triglycerides, serum low density lipoprotein cholesterol and serum high density lipoprotein cholesterol was performed and results were compared. Offsprings of parents having more number of risk factors had statistically significantly high total cholesterol and low density lipoprotein cholesterol as compared with offsprings of parents having one risk factor. Triglycerides and high density lipoprotein cholesterol of offsprings of parents having one, two, three or more than three risk factors were comparable. Offsprings of parents having premature coronary heart disease [CHD] had abnormal lipid levels as compared with control group. Coronary heart disease risk factors are significant regarding abnormal lipid levels. Offsprings of premature CHD patients are prone to develop CHD as compared to normal control group. Genetic predisposition seems to be important in development of CHD