Aminoaciduria: a possible marker of renal tubular damage in children with collagen vascular disease [CVD]

ABSTRACT

Forty seven children with CVD and fifty age and sex matched controls was studied. Careful clinical evaluation and laboratory investigations were carried out to both cases and controls. C reactive protein [CRP] and rheumatoid factor [by latex] were unsuitable for diagnosing [CVD]. Antinuclear antibodies [ANA] were highly positive among SLE group versus the other groups and controls. However ANA-ve SEL, cases were also found. Anti-ds DNA antibodies were highly specific for SEL. 68.1% of CVD patients had renal involvement whether in the form of an abnormal urinary sediment or elevated serum urea and creatinine. Most had an abnormal urinary amino-gram. In some cases an elevated urinary amino-aciduria was the only evidence of renal affection. Proteinuria correlated positively with amino-aciduria