study of bone mineral density in diabetic patients

ABSTRACT

In view of the current high prevalence of diabetes mellitus [DM] and osteoporosis, today there is great interest in studying the possible association between these two disorders. The aim of this study was to determine the association between type-2 DM, and Bone mineral density [BMt]] in Iranian women. BMD was determined in the femoral neck and at the L2-L4 level [DEXA] Of 518 women aged 40-80 years old, referred to bone densitometry unit of Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences [146 patients with type 2 diabetes and 372 normal controls]. In diabetics patients, BMD values at the vertebral site were higher than non-diabetic patients but the difference was only significant in postmenopausal subgroup [P= 0.045]. Besides, BMD values at the hip site were higher when com-pared with non-diabetes group, but the difference was not significant. Frequency of osteoporosis risk factors [tea consumption, sunlight exposure, late menarche, low physical activity, smoking habits, family history of osteoporosis and inadequate calcium intake] were not significantly different between diabetic and non-diabetic women, but prevalence of early menopause was higher in diabetic women [P= 0.046]. Prevalence of osteoporosis in premenopausal and postmenopausal was 7% and 41.6% in diabetic and 15% and 36.8% in non-diabetic women, respectively. Prevalence of osteoporosis and osteopenia was not significantly different in diabetic and non-diabetic groups. The present results demonstrate that there is not clear association between BMD and type 2 diabetes mellitus