Neonatal langerhan's cell histiocytosis; early presentation with delayed diagnosis

ABSTRACT

Neonatal Langerhan's cell histiocytosis [LCH] is a rare disease which presents in the first four weeks of life with skin manifestations; although the diagnosis may be delayed till other organ involvement becomes apparent. We describe a four-month-old male infant who presented with skin lesions in the neonatal period and was diagnosed later, when involvement of lymph nodes, liver, spleen and bone became apparent. Due to the possibility of clinically unapparent involvement of other organ systems in neonatal LCH, thorough clinical, laboratory and imaging studies are mandatory for a comprehensive evaluation of all cases on presentation