Influence of genetic polymorphisms of glutathione S-transferases Tl and Ml on serum lipid parameters

ABSTRACT

To determine the effect of genetic polymorphisms of glutathione S-transferase theta 1 [GSTTl] and GSTM1 on serum levels of lipid parameters. We conducted this cross-sectional study on 152 adult healthy subjects [54 females and 98 males] from June 2004 to September 2004. The participants in our study were recruited from the Research Clinic in Abarku [Yazd province, central part of Iran]. There were unrelated Iranian Muslims. The genotypes of GSTTl and GSTM1 were determined using a polymerase chain reaction based method. After an overnight fasting, serum lipid indices including triglyceride [TG], total cholesterol [TC] and high density lipoprotein cholesterol [HDL-C] were measured. There were significant partial correlation coefficients between levels of TG [r= -0.4833, df=48, P<0.001] andTG/HDL-C ratio [r= -0.4041, df=48, P=0.004] and numbers of active GST genotypes in females after controlling for age and body mass index [BMI]. In males, the level of TG increased as a function of numbers of active GST genotypes after controlling for age and BMI [r= +0.2082, df=94, P=0.042]. There were significant differences between females and males. Data show that genetic polymorphisms of GSTM 1 and GSTTl modulate levels ofTG, andTG/HDL-C in females