Cardiac toxicity in breast cancer patients
GJO-Gulf Journal of Oncology [The]. 2014; (15): 49-55
in English
| IMEMR
| ID: emr-139697
ABSTRACT
To asses cardiac toxicity post radiotherapy in left cancer breast patients with different fractionations. This is a prospective randomized study conducted at Kasr El-Ainy Center of Clinical Oncology and Nuclear Medicine [NEMROCK]. Cardiological assessment using RTOG toxicity criteria was done for left sided breast cancer patients after at least five years of conformal radiation therapy. There were two arms of radiation, conventional [50Gy/25sttt/5 Ws] and hypofractionation [42.5 Gy 716 fractions /3 1/5 weeks]. Thirty patients were included in each arm. After a median follow up of 62 months [range 60 to 72], cardiac dysfunction developed more in the conventional arm but was insignificant [P value =0.36]. Grade I and II toxicity was 83.3 vs 70% and grade III was 3.3% in the hypofractionated arm only. The rate of local-regional tumor relapse at 5 years was similar [3.3%]. Hypofractionated radiotherapy decreased cardiac toxicity though not statistically significant, however it is more cost effective and time consuming
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Radiotherapy
/
Prospective Studies
/
Heart Diseases
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
Language:
English
Journal:
Gulf J. Oncol.
Year:
2014
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