Serum cortisol levels as a predictor of neurologic survival in successfully resuscitated victims of cardiopulmonary arrest
JCVTR-Journal of Cardiovascular and Thoracic Research. 2012; 4 (4): 107-111
in English
| IMEMR
| ID: emr-139756
ABSTRACT
Out-of-hospital cardiac arrest [OHCA] is the most stressful lifetime event for the victims and an important issue for the emergency physicians. The status of the hypothalamic pituitary- adrenal axis [HPA] function in successfully resuscitated victims of Cardiopulmonary arrest has been recently of an interest for the researchers. In a prospective cohort study, 50 successfully resuscitated OHCA victims' serum cortisol levels were measured 5 minutes and 1 hour after return of spontaneous circulation [ROSC]. The data were analyzed comparing the one-week neurologic survival. Fifty blood samples were obtained for serum cortisol levels after 5 minutes of ROSC. Fourteen patients [28%] pronounced death during one hour after CPR. Blood sample from living 36 patients after one hour post-CPR were obtained for second cortisol assay. Eleven patients [22%] were neurologically survived after one week. Seven patients [14%] were discharged finally from hospital with good neurologic recovery. The serum cortisol levels in both the neurologically surviving and the non-surviving after 5 minutes of ROSC patients were 63.4 +/- 13.6 and 43.2 +/- 25.5[microg/ml], [mean +/- S.D., respectively] and after 1 hour of ROSC patients' serum cortisol levels were 64.9 +/- 13.1 and 47.3 +/- 27.1[microg/ml], [mean +/- S.D., respectively]. The difference was significantly higher in neurologically survived group in both 5 minutes and 1 hour after ROSC [P= 0.015 and 0.013 respectively]. serum cortisol levels after 5 minutes and one hour of ROSC in victims of Cardiopulmonary arrest are significantly higher in neurologically survived than non-survived patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Predictive Value of Tests
/
Prospective Studies
/
ROC Curve
/
Cohort Studies
/
Outcome Assessment, Health Care
/
Cardiopulmonary Resuscitation
/
Heart Arrest
Type of study:
Incidence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Cardiovasc. Thorac. Res.
Year:
2012
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