Analysis of the serological reactivity and haplotypes of HLA-B*37:02 allele

ABSTRACT

Of 73355 subjects HLA typed in our laboratory, 644 were positive for B37 with only 2 positive for B3702. The serological reactivity of both cells and probable haplotypes was analyzed. The serological reactivity was similar for both cells with BW4 positivity. Both cells reacted positively to poly specific sera with B37, B*27, B47 and B*13 reactivity. Interestingly, neither of the cells reacted to operationally monospecific sera with B27, B37, or B47 reactivity or to poly specific sera with B27 and 837 reactivity. No poly-specific sera with B37 and B47 reactivity were available for testing. A population genetics approach based on reported haplotypes frequencies suggest that the most probable haplotypes for both cells are A 2402 B* 1801 C*0501 DRB1* 0301 and A*01OJ B*3702 C*0202 DRB1*1104 for the first cell and A*2902 B* 1402 C*0202 DRB1* 0701 and A*30 8*3702 ! C*0202 ORB I