Performance evaluation of a novel potentiometric membrane sensor for determination of atorvastatin in pharmaceutical preparations

ABSTRACT

A novel potentiometric ion-selective PVC membrane sensor for analysis of atorvastatin [AT] in pharmaceutical preparations based on atorvastatin-[tetraphenyl borate] [AT-[TPB][2] as sensing element, tetraphenyl borate as additive and tris-2-ethyl-hexyl phosphate [TOP] as plasticizer solvent was prepared. The electrode shows a good Nernestian response over the concentration range of 0.09-5586 microg ml/of AT with slope of 30.1 +/- 0.1 mV/decade and limit of detection0.056microg ml.The response time of sensor is fats [less than 10 sec] and could be used for about one month in the pH range of 4.5-8.0. The electrode exhibit good selectivity for the AT in the presence of large amount of co-drugs and inorganic cations. The method is precise and accurate with mean relative standard deviation of <2%.Atorvastatin is determined successfully in several tablets by the proposed membrane