Synthesis and analgesic activity of novel hydrazide and hydrazine derivatives

ABSTRACT

The uses of non-steroidal anti-inflammatory drugs [NSAIDs] are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds l0a-l0e and 15a-15d were prepared by condensation of corresponding hydrazides 7, 8 and 11-14 with different aldehydes 9a-9e. The structures of all synthesized compounds were confirmed by means of FT-IR, H-NMR and Mass spectra. All compounds were evaluated for their analgesic activities by abdominal constriction test [writhing test]. Most of the synthesized compounds induced significant reduction in the writhing response when compared to control and compound 15 was more potent than mefenamic acid in the writhing test