Effects of captopril vs amlodipine on blood pressure, serum glucose and lipid profile in overweight and obese hypertensive patients

ABSTRACT

To investigate the effects of captopril vs amlodipine on blood pressure, BMI, serum glucose concentration and lipid profile in overweight and obese hypertensive patients. This study was conducted on two groups of overweight and obese newly diagnosed stage 1 hypertensive patients; captopril group included 42 patients who were kept on captopril monotherapy and amlodipine group included 41 patients who were kept on amlodipine monotherapy. Another 40 apparently healthy normotensive individuals were used as a control group. The patients were placed on captopril or amlodipine for 8 weeks. Systolic and diastolic BP, body weight, BMI, fasting serum glucose and lipid profile were measured before and at the end of trial. After 8 weeks of treatment with captopril or amlodipine the measured parameters are significantly reduced but comparison of each group revealed no significant differences except Fasting Glucose, where a higher reduction was seen with captopril. Both captopril and amlodipine were effective in the treatment of hypertension in overweight and obese patients. In addition, both drugs had beneficial effects on body weight, serum glucose concentration and lipid profile