[Effect of lidocaine on duration of seizure and hemodynamic alterations in electroconvulsive therapy]

ABSTRACT

Electroconvulsive therapy [ECT] is one of the most common methods in treatment of different types of psychological disorder. The effectiveness of this therapy has a direct relation with the duration of convulsion. This study was conducted to assess the effect of lidocaine on duration of seizure and hemodynamic alterations in electroconvulsive therapy. This clinical trial study was conducted on 72 ASA-I, II patients with psychotic disorders in Hajar Medical Center in Shahrekord, Iran during 2010. The patients randomly divided into intervention and control group. The interventional group was received 1.5 mg/kg lidocaine and controls were received normal saline. For induction of anesthesia, all patients were received Sodium Thiopental [2mg/kg], Succinylcholine [1mg/kg] and Atropine [0.5mg] Propofol and Succinylcholine during 72 sessions of ECT. Duration of objective convulsion and hemodynamic alterations including blood pressure and heart rate were recorded [before, immediately and 3, 5 minutes after ECT]. Data were analyzed using SPSS-11.5 and t-test. Systolic and diastolic blood pressures and heart rate in 3rd minutes in interventional group following electroconvulsive therapy were 143.38 +/- 16 mmHg, 79.86 +/- 6.7 mmHg, 91.9 +/- 9.9 mmHg, respectively and in controls were 128.88 +/- 13.04 mmHg, 87.63 +/- 5.79 mmHg and 102.86 +/- 13 mmHg, respectively. These difference were significant [P<0.05]. The above-mentioned indices for 5th minutes in intervention and controls were as follow systolic [113.47 +/- 9.97 mmHg, 122.36 +/- 13 mmHg], diastolic [73.47 +/- 4.27 mmHg, 77.63 +/- 6.26 mmHg] heart rate [84.41 +/- 4.6 in minute, 93.19 +/- 12.53 in minute]. These differences in above indices were significant [P<0.05]. This study showed that lidocaine administration during electroconvulsive therapy increase the duration of convulsion and reduces heart rate and blood pressure