Alteration of the K-ras gene expression in atypical and nonatypical hyperplastic endometrium
Iranian Journal of Cancer Prevention. 2013; 6 (4): 209-213
in English
| IMEMR
| ID: emr-141006
ABSTRACT
Endometrial cancer is the most common gynecologic malignancy that has often proceeded by a premalignant phase. Modern molecular and immunostaining methods for precancerous lesions diagnosis have been expanded. One of the genetic alternations in the endometrial cancer carcinogenesis is the mutational activation of the K-ras oncogene. K-ras mutation has recognized to occur at an early stage of neoplastic progression in the endometrium. The purpose of this study is to investigate the expression pattern of K-ras gene in atypical and nonatypical hyperplastic endometrium. In a prospective study in the referral gynecologic hospital in Tehran, immunohistochemical evaluation of K-ras has performed on 72 consecutive specimens in two following groups endometrial hyperplasia without atypia [n 36], and endometrial hyperplasia with atypia [n 36]. Staining of cells has evaluated in arbitrary quantitative methods in regards to both slides area staining and intensity of color reaction. K-ras immunoreactivity has seen in 3/36 [8.3%] cases of non atypical hyperplasia and in 2/36 [5.6%] cases of atypical hyperplasia [P 0.64]. We have not establish any significant differences in K-ras expression between the atypical and nonatypical hyperplastic endometrium, and our data has supported this view that K-ras mutation is a very rare event in human endometrial carcinogenesis
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunohistochemistry
/
Gene Expression
/
Prospective Studies
/
Endometrial Neoplasms
/
Endometrial Hyperplasia
Limits:
Female
/
Humans
Language:
English
Journal:
Iran. J. Cancer Prevention
Year:
2013
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