[Effect of salvia officinalis L. extract on malondialdehyde against streptozotocin-induced oxidative stress in rat's brain]

ABSTRACT

Oxidative stress is caused by an imbalance between oxidative and the anti-oxidative systems in the living tissues. Oxidative stress in brain causes brain dysfunction, destruction of neurons, and diseases like Alzheimer. In the present study, we examined the protective effect of Salvia officinalis L. against streptozotocin-induced oxidative stress in rat's brain. In this experimental study, Wistar rats were divided into control, Sham, and three experimental groups received 25, 50 and 100 mg/kg hydroalcoholic extract of Salvia officinalis intraperitoneally, respectively. After two weeks, surgical procedure was performed on sham and experimental groups and after one week recovery, streptozotocin was injected intra-cerebroventricularly [ICV-STZ] at 3 mg/kg. Brain hemispheres were collected after fourth week. Finally, malondialdehyde [MDA]] level was measured in brain hemispheres tissues. STZ significantly increased MDA levels compared to the control group [P<0.001], whereas intraperitoneally injection of different doses of Salvia officinalis leaves extract significantly decreased MDA levels [P<0.001]. We concluded that antioxidant effect of Salvia officinalis L. could prevent oxidative stress induced by ICV injection of STZ in the brain of male rat