Clinical osteoporosis probability scoring system: selection of menopausal women for bone densitometry screening

ABSTRACT

To formulate a clinical scoring system for evaluating people at risk of osteoporosis before ordering Bone Mass Densitometry. Eighty two probable clinical osteoporosis related factors were checked in 325 females referred for Bone Mass Densitometry testing in Hamadan province, Iran. The statistical modeling resulted in a clinical osteoporosis probability [COP] scoring system based on 9 factors including fracture history, drug therapy with thyroid hormone, corticosteroids, estrogen, ca-VitD, number of children, age, BMI and the number of menopausal years. Osteoporosis was found in 62.2%. The osteoporosis probability scoring system cutoff value of 26.8 was selected with 89% sensitivity, 63% specificity, Youden factor of 0.53 and LR=2.4. In this score, osteoporosis probability was 98%. Area under the curve in Roc curve of osteoporosis probability scoring system was 81.4%. Clinical Osteoporosis Probability scoring system with a 26.8 cutoff value is suggested for osteoporosis prescreening using Bone Mass Densitometry test