Lysozymuria could be a marker for early aminoglycoside snephrotoxicity

ABSTRACT

This work was designed to study the urinary lysozyme as a marker for early detection of aminoglycosides nephrotoxicity. 15 patients were selected to be the subject of this study and 11 normal individuals were included for comparison. For each subject the following were done blood glucose, BUN, creatinine urine creatinine, creatinine clearance, serum and urinary lysozyme. These tests were done before treatment, two days after the start of treatment and two days after the end of treatment with aminoglycosides. This study revealed that aminoglycosides have reversible nephrotoxicity as indicated by the significant rise in the urinary lysozyme during aminoglycosides therapy with its subsequent fall to baseline values 48 hours after stopping the treatment. Aminoglycosides nephrotoxicity is tubular and not glomerular in origin as indicated by normal creatinine clearance value through the entire period of treatment. Therefore serum creatinine and creatinine clearance should not be used to monitor aminoglycosides nephrotoxicity