Allopurinol as a preventive contrivance after acute ischemic stroke in patients with a high level of serum uric acid: a randomized, controlled trial
Medical Principles and Practice. 2014; 23 (2): 134-139
in English
| IMEMR
| ID: emr-141962
ABSTRACT
To assess the clinical relevance [functional outcome] of a 3-month allopurinol regimen in patients with high serum uric acid [SUA] levels and acute ischemic stroke without considering the changes in SUA levels. In a randomized, double-blind, controlled study, 70 patients [45 females, 25 males] with acute ischemic stroke who had elevated levels of SUA were included. They were divided in two 35-patient groups to investigate the effect of 3 months of an allopurinol [200 mg/day] regimen versus placebo on their functional outcome, which was evaluated using a modified Rankin scale. The overall mean age was 68.9 +/- 11.33 years [range 27-89]. The final favorable functional status [mRS = 0-2] was 23 [65.7%] and 14 [40.0%] in the treated and placebo groups, respectively, which was strongly associated with allopurinol consumption [OR = 4.646, p = 0.014] and age = 70 years [OR = 0.139, p = 0.005] in patients with ischemic stroke after adjusting for confounders. There was no significant difference in death between allopurinol-treated cases [3; 8.6%] and placebo-treated ones [6; 17.2%; p = 0.278]. Allopurinol treatment was well tolerated and improved the 3-month functional status of patients with acute ischemic stroke who had high levels of SUA without considering the decreasing effect of allopurinol on SUA
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Uric Acid
/
Xanthine Oxidase
/
Double-Blind Method
/
Acute Disease
/
Stroke
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. Princ. Pract.
Year:
2014
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